Comparative pharmacological properties between ethanolic extracts of Phyllanthus acidus P. and Sonneratia apetala L. on Swiss albino mice

Abstract

Objectives: The present study was designed to evaluate and compare antidiabetic, analgesic activities of ethanolic extract of phyllanthusacidus and    Sonneratiaapetala. We carried out this work to explore the medicinal uses of very common and cheap fruity plant among the people of all classes. Methods: The antidiabetic activity was evaluated and compared by studying the effect of ethanolic extract of Phyllanthus acidus (EEPA) and Sonneratia apetala (EESA) against blood glucose level of alloxan-induced diabetic mice in every 4 h for 16 h. To evaluate and compare analgesic, activities different tests such as acetic acid-induced writhing test. Results: The mice were treated with both plants extract at a dose of 250 & 500 mg/kg body weight in case of antidiabetic activity test. Blood glucose level was examined and found that there was a significant reduction of blood glucose level with EEPA (p<0.05)  and EESA (p<0.05) extracts were given at a dose of 250 mg/kg body weight showed significant (p<0.05) reduction of blood glucose level with a mean value from 19.08±2.59873*mmol/L to 9.4±2.111871 mmol/L and 14.6±1.025183*mmol/L to 8.66±0.604649mmol/L. EEPA and EESA was given at a dose 500 mg/kg body weight showed significant (p<0.05)  decreased blood glucose from 23.8±6.755738 mmol/L to 8.86±1.80599*** mmol/l (± SEM) and 16.16±2.441229 to 9.825±0.702822***mmol/L (± SEM) in comparison with their respective diabetic control group.  Although both plant extracts reduced the blood glucose level, the glucose reducing effect was higher in EEPA. Both the plants EEPA at a dose of 500 mg/kg and EESA and at a dose of 250 mg/kg body weight showed significant (p<0.05) analgesic effect with with percentage of inhibition 32.55% and 21.70% respectively. EEPA at a dose of 250 mg/kg and EESA at a dose of 500 mg/kg body weight showed significant (p<0.05) analgesic effect with with percentage of inhibition 67.44% and 52.71% respectively. The analgesic activity in treated mice but less significant central analgesic activity. EEPA showed higher peripheral analgesic activity than EESA. Conclusions: In this study, showed highly sufficient antidiabetic property in plant of Sonneratia   Phyllanthus acidus and highly significant analgesic activity, thus administration of noil and keora may be useful for diabetic people. Keora may be more helpful for diabetic people than noil.